Integrated genomic and function characterization of the 8q22 gain
Integrated DNA and expression array analysis in primary human breast tumors identified chromosome 8q22 copy number gain and a suite of over-expressed genes in this region highly relevant to subsequent recurrence. 8q copy gain is associated with increased risk of distant metastasis despite adjuvant chemotherapy and multiple genes from 8q22 are overexpressed and have pleiotropic effects, contributing to tumor growth, survival, and reduced killing of tumor cell by chemotherapy.
Provenance — who produced it, who reused it
Linked to 68 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Survival analysis across the entire transcriptome identifies bio... 2021 · 1,740 cites
- Aerobic glycolysis tunes YAP/TAZ transcriptional activity 2015 · 420 cites
- A Three-Gene Model to Robustly Identify Breast Cancer Molecular... 2012 · 328 cites
- TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer 2012 · 303 cites
- LINC02273 drives breast cancer metastasis by epigenetically incr... 2019 · 222 cites
- Amplification and high-level expression of heat shock protein 90... 2012 · 183 cites
- Actin stress fiber organization promotes cell stiffening and pro... 2017 · 182 cites
- Changes of N6-methyladenosine modulators promote breast cancer p... 2019 · 168 cites
- Downregulation of long noncoding RNA MALAT1 induces epithelial-t... 2015 · 151 cites
- EMT is associated with an epigenetic signature of ECM remodeling... 2019 · 148 cites
- HMGA1 promotes metastatic processes in basal-like breast cancer... 2013 · 134 cites
- DEAD-box helicase DP103 defines metastatic potential of human br... 2014 · 131 cites
- Portraying breast cancers with long noncoding RNAs 2016 · 116 cites
- The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to... 2019 · 92 cites
- Reprogramming of Amino Acid Transporters to Support Aspartate an... 2019 · 83 cites
- Downregulation of the FTO m6A RNA demethylase promotes EMT-media... 2021 · 78 cites
- FADS1/2 control lipid metabolism and ferroptosis susceptibility... 2024 · 77 cites
- SPHK1 regulates proliferation and survival responses in triple-n... 2014 · 73 cites
50 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently