Gene expression profiling of multiple myeloma patients included in the HOVON65/GMMG-HD4 trial
In order to identify relevant, molecularly defined subgroups in Multiple Myeloma (MM), gene expression profiling (GEP) was performed on purified CD138+ plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/ GMMG-HD4 trial using Affymetrix GeneChip U133 plus 2.0 arrays. Hierarchical clustering identified 10 distinct subgroups. Using this dataset as training data, a prognostic signature was built. The dataset consists of 282 CEL files previously used in...
Provenance — who produced it, who reused it
Linked to 23 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation... 2017 · 150 cites
- Transient loss of Polycomb components induces an epigenetic canc... 2024 · 147 cites
- The proliferative history shapes the DNA methylome of B-cell tum... 2020 · 104 cites
- Removing batch effects from purified plasma cell gene expression... 2015 · 99 cites
- Destabilizing NEK2 overcomes resistance to proteasome inhibition... 2018 · 91 cites
- Ferroportin downregulation promotes cell proliferation by modula... 2019 · 91 cites
- CHEK1 and circCHEK1_246aa evoke chromosomal instability and indu... 2021 · 73 cites
16 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently