KLF1/EKLF regulatory networks in primary erythroid cells
KLF1 (EKLF) regulates a diverse suite of genes to direct erythroid cell differentiation from bi-potent progenitors. To determine the local cis-regulatory contexts and transcription factor networks in which KLF1 operates, we performed KLF1 ChIP-seq in the mouse. We found at least 945 sites in the genome of E14.5 fetal liver erythroid cells which are occupied by endogenous KLF1. Many of these recovered sites reside in erythroid gene promoters such as β-globin, but the majority are distant to any k...
Provenance — who produced it, who reused it
Linked to 6 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Genomic modelling of the ESR1 Y537S mutation for evaluating func... 2016 · 178 cites
- Predicting the three-dimensional folding of cis-regulatory regio... 2016 · 132 cites
- Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq 2012 · 108 cites
- Many chronological aging clocks can be found throughout the epig... 2021 · 71 cites
2 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently