Mutated KRAS induces overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas
Mutations of the KRAS oncogene are predictive for resistance to treatment with antibodies against the epithelial growth factor receptor in patients with colorectal cancer. Overcoming this therapeutic dilemma could potentially be achieved by the introduction of drugs that inhibit signaling pathways that are activated by KRAS mutations. To comprehensively identify such signaling pathways we profiled pretreatment biopsies from 65 patients with locally advanced rectal cancer – 30 of which carried mu...
Provenance — who produced it, who reused it
Linked to 20 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- The Rectal Cancer microRNAome – microRNA Expression in Rectal Ca... 2012 · 183 cites
- Spermine synthase and MYC cooperate to maintain colorectal cance... 2020 · 116 cites
- Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Depe... 2018 · 95 cites
- TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-... 2018 · 94 cites
- TRIP13 promotes tumor growth and is associated with poor prognos... 2018 · 89 cites
15 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently