Whole-transcript and exon-level expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate
Current knowledge of prostate cancer genomes is largely based on relatively small patient cohorts using single modality analysis platforms. Here we report concordant assessment of DNA copy number, mRNA and microRNA expression and focused exon resequencing in prostate tumors from 218 patients with primary or metastatic prostate cancer with a median of 5 years clinical follow-up, now made available as a public resource. Mutations in known, commonly mutated oncogenes and tumor suppressor genes such...
Provenance — who produced it, who reused it
Linked to 81 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Integrative genomic analyses reveal clinically relevant long non... 2013 · 545 cites
- LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcript... 2015 · 341 cites
- Integrative analyses reveal a long noncoding RNA-mediated sponge... 2016 · 325 cites
- N‐myc downstream regulated gene 1 modulates Wnt‐β‐catenin signal... 2012 · 200 cites
- 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatme... 2020 · 189 cites
- Lipid-loaded tumor-associated macrophages sustain tumor growth a... 2021 · 183 cites
- TRIM28 protects TRIM24 from SPOP-mediated degradation and promot... 2018 · 153 cites
- Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes t... 2016 · 125 cites
- Exosome proteomic analyses identify inflammatory phenotype and n... 2019 · 117 cites
- ACSS3 represses prostate cancer progression through downregulati... 2020 · 117 cites
- MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Pr... 2012 · 103 cites
- SPDEF Inhibits Prostate Carcinogenesis by Disrupting a Positive... 2014 · 97 cites
- YAP1 overexpression contributes to the development of enzalutami... 2021 · 85 cites
- MiRNA-671-5p Promotes prostate cancer development and metastasis... 2020 · 84 cites
- ATR inhibition controls aggressive prostate tumors deficient in... 2018 · 78 cites
- GLUT12 promotes prostate cancer cell growth and is regulated by... 2018 · 75 cites
64 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently