Mammalian microRNAs predominantly act to decrease target mRNA levels
MicroRNAs (miRNAs) are endogenous ~22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression. Repression of these regulatory targets leads to decreased translational efficiency and/or decreased mRNA levels, but the relative contributions of these two outcomes have been largely unknown, particularly for endogenous targets expressed at low-to-moderate levels. Here, we use ribosome profiling to measure the overall eff...
Provenance — who produced it, who reused it
Linked to 9 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Pervasive Transcription of the Human Genome Produces Thousands o... 2013 · 755 cites
- Identification of small ORFs in vertebrates using ribosome footp... 2014 · 728 cites
- Long non-coding RNAs as a source of new peptides 2014 · 559 cites
- mRNA Destabilization Is the Dominant Effect of Mammalian MicroRN... 2014 · 502 cites
- Analysis of CDS-located miRNA target sites suggests that they ca... 2013 · 343 cites
- Observation of dually decoded regions of the human genome using... 2012 · 225 cites
3 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently