miR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues from a cohort of 96 HCC patients in Hong Kong where hepatitis B virus (HBV) is endemic. The comprehensive analysis of the coordinate expression of miRNAs and mRNAs reveals that miR-122 is under-expressed...
Provenance — who produced it, who reused it
Linked to 80 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- A circRNA–miRNA–mRNA network identification for exploring underl... 2018 · 301 cites
- miR-182-5p promotes hepatocellular carcinoma progression by repr... 2018 · 241 cites
- microRNA-146a inhibits cancer metastasis by downregulating VEGF... 2015 · 135 cites
- Suppression of CYP2C9 by MicroRNA hsa-miR-128-3p in Human Liver... 2015 · 132 cites
- miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hep... 2014 · 130 cites
- Genomic Predictors for Recurrence Patterns of Hepatocellular Car... 2014 · 120 cites
- MicroRNA-494 within an oncogenic microRNA megacluster regulates... 2013 · 115 cites
- Differentiation therapy for hepatocellular carcinoma: Multifacet... 2015 · 110 cites
- MicroRNA-31 functions as a tumor suppressor by regulating cell c... 2015 · 108 cites
- SSRP1 Contributes to the Malignancy of Hepatocellular Carcinoma... 2016 · 97 cites
- miR-125b-5p inhibits cell proliferation, migration, and invasion... 2019 · 94 cites
- Integrative analysis of gene and miRNA expression profiles with... 2012 · 91 cites
- Oncogenic potential of histone-variant H2A.Z.1 and its regulator... 2016 · 83 cites
- Centrality-based pathway enrichment: a systematic approach for f... 2012 · 79 cites
- MYC‐driven inhibition of the glutamate‐cysteine ligase promotes... 2017 · 77 cites
- EYA2 suppresses the progression of hepatocellular carcinoma via... 2021 · 75 cites
- APEX1 is a novel diagnostic and prognostic biomarker for hepatoc... 2020 · 71 cites
62 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently