Control of Embryonic Stem Cell State by Mediator and Cohesin (Illumina ChIP-Seq data)
The key transcription factors that control the embryonic stem cell gene expression program have been identified, but how they function to implement this program is not well understood. While screening for genes essential for maintenance of ES cell state, we identified many components of the Mediator and Cohesin complexes. Mediator and Cohesin were found to physically and functionally connect the enhancers and core promoters of active genes. An ES cell Mediator complex was found to copurify wi...
Provenance — who produced it, who reused it
Linked to 17 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Multiscale 3D Genome Rewiring during Mouse Neural Development 2017 · 1,474 cites
- Local regulation of gene expression by lncRNA promoters, transcr... 2016 · 1,348 cites
- Distinct Classes of Chromatin Loops Revealed by Deletion of an R... 2019 · 275 cites
- Enhancer accessibility and CTCF occupancy underlie asymmetric TA... 2019 · 113 cites
- Enhancer identification in mouse embryonic stem cells using inte... 2012 · 78 cites
12 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently