DNA methylation signatures define molecular subtypes of Diffuse Large B Cell Lymphoma
We performed DNA methylation (HELP) and gene expression profiling in 69 samples of diffuse large B cell lymphoma (DLBCL). First, by gene expression, two molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL were assigned to the 69 DLBCL cases. Then, we performed supervised analysis using HELP data and defined DNA methylation signature differentiating 2 subgroups of DLBCLs.
Provenance — who produced it, who reused it
Linked to 4 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Clinical and Biological Subtypes of B-cell Lymphoma Revealed by... 2021 · 250 cites
- TET1 is a tumor suppressor of hematopoietic malignancy 2015 · 226 cites
- Aberration in DNA Methylation in B-Cell Lymphomas Has a Complex... 2013 · 123 cites
- Surface Proteomics Reveals CD72 as a Target for <i>In Vitro</i>... 2021 · 81 cites
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently