Densely interconnected transcriptional circuits control cell states in human hematopoiesis
Tremendous progress has been made in identifying individual transcription factors that regulate hematopoietic differentiation, but many aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression patterns and sequence-based analysis of motifs in gene promoters to decipher the general organization of their regulatory circuitry. We identified m...
Provenance — who produced it, who reused it
Linked to 36 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- xCell: digitally portraying the tissue cellular heterogeneity la... 2017 · 4,663 cites
- A clinically meaningful metric of immune age derived from high-d... 2019 · 535 cites
- Digital sorting of complex tissues for cell type-specific gene e... 2013 · 241 cites
- Population-scale tissue transcriptomics maps long non-coding RNA... 2021 · 212 cites
- The non-coding RNA landscape of human hematopoiesis and leukemia 2017 · 165 cites
- Targeting MTHFD2 in acute myeloid leukemia 2016 · 165 cites
- Musashi-2 attenuates AHR signalling to expand human haematopoiet... 2016 · 144 cites
- The metabolic enzyme hexokinase 2 localizes to the nucleus in AM... 2022 · 94 cites
- In Vivo Mapping of Notch Pathway Activity in Normal and Stress H... 2013 · 89 cites
- RBFOX2 recognizes N6-methyladenosine to suppress transcription a... 2023 · 86 cites
- Compressing gene expression data using multiple latent space dim... 2020 · 83 cites
- Differential co-expression-based detection of conditional relati... 2019 · 81 cites
- Intercellular network structure and regulatory motifs in the hum... 2014 · 80 cites
23 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently