Study of gene expression of human liver Hepatocellular carcinoma
Hepatocellular carcinoma (HCC) affects millions of people worldwide and is a lethal malignancy for which there are no effective therapies. To identify prognostic gene markers for liver cancer, we conducted transcriptome profiling of frozen tissues (tumor and non-tumor) from 300 early-to-advanced stage HCCs plus 40 cirrhotic and 6 normal livers.
Provenance — who produced it, who reused it
Linked to 140 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Comprehensive analysis of normal adjacent to tumor transcriptome... 2017 · 647 cites
- Circular RNA circRHOT1 promotes hepatocellular carcinoma progres... 2019 · 445 cites
- Targeting glutaminase 1 attenuates stemness properties in hepato... 2018 · 239 cites
- Sphingolipid Metabolic Pathway: An Overview of Major Roles Playe... 2013 · 193 cites
- A single H/ACA small nucleolar RNA mediates tumor suppression do... 2019 · 141 cites
- Downregulation of exosomal CLEC3B in hepatocellular carcinoma pr... 2019 · 138 cites
- The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability a... 2019 · 128 cites
- Diverse modes of genomic alteration in hepatocellular carcinoma 2014 · 124 cites
- Drp1-mediated mitochondrial fission promotes cell proliferation... 2016 · 105 cites
- Early Diagnosis of Hepatocellular Carcinoma Using Machine Learni... 2020 · 97 cites
- MiR-126 negatively regulates PLK-4 to impact the development of... 2018 · 86 cites
- Identification of Chemical Inhibitors of β-Catenin-Driven Liver... 2015 · 81 cites
- LDLR inhibition promotes hepatocellular carcinoma proliferation... 2021 · 77 cites
- PHLDA3 overexpression in hepatocytes by endoplasmic reticulum st... 2015 · 76 cites
- P53 deficiency affects cholesterol esterification to exacerbate... 2022 · 75 cites
- Xmrk, Kras and Myc Transgenic Zebrafish Liver Cancer Models Shar... 2014 · 74 cites
- APEX1 is a novel diagnostic and prognostic biomarker for hepatoc... 2020 · 71 cites
62 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently