Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer’s disease
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that threatens to reach epidemic proportions as our population ages. Although much research has examined molecular pathways associated with AD, relatively few studies have focused on critical early stages. Our prior microarray study correlated gene expression in human hippocampus with AD markers. Results suggested a new model of early-stage AD in which pathology spreads along myelinated axons, orchestrated by upregulated transc...
Provenance — who produced it, who reused it
Linked to 51 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Conserved epigenomic signals in mice and humans reveal immune ba... 2015 · 638 cites
- Identifying phenotype-associated subpopulations by integrating b... 2021 · 518 cites
- Tau promotes neurodegeneration through global chromatin relaxati... 2014 · 496 cites
- Dysregulation of the epigenetic landscape of normal aging in Alz... 2018 · 379 cites
- Sphingolipid Metabolic Pathway: An Overview of Major Roles Playe... 2013 · 193 cites
- Bioinformatics and Network Pharmacology Identify the Therapeutic... 2021 · 87 cites
- A Network-Based Bioinformatics Approach to Identify Molecular Bi... 2020 · 75 cites
44 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.