Transcriptome Analysis Identifies Fn14, a TNF Superfamily Receptor Member, as a Therapeutic Target in Alcoholic Hepatitis
Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease and occurs in patients with excessive alcohol intake It is characterized by marked hepatocellular damage, steatosis and pericellular fibrosis. Patients with severe AH have a poor short-term prognosis. Unfortunately, current therapies (i.e. corticosteroids and pentoxyphylline) are not effective in many patients and novel targeted therapies are urgently needed. The development of such therapies is hampered by a poor knowle...
Provenance — who produced it, who reused it
Linked to 23 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Alcohol dysregulates miR-148a in hepatocytes through FoxO1, faci... 2018 · 249 cites
- Transcriptional activation of Fsp27 by the liver‐enriched transc... 2014 · 101 cites
- Epigenetic signatures of alcohol abuse and hepatitis infection d... 2014 · 97 cites
- Integrated Multiomics Reveals Glucose Use Reprogramming and Iden... 2020 · 77 cites
- miR-135b Stimulates Osteosarcoma Recurrence and Lung Metastasis... 2017 · 75 cites
18 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently