MicroRNA sequence and expression analysis in breast tumors by deep sequencing
MicroRNAs (miRNAs) regulate many genes critical for tumorigenesis. We profiled miRNAs from 11 normal breast tissues, 17 non-invasive, 151 invasive breast carcinomas, and 6 cell lines by in-house-developed barcoded Solexa sequencing. miRNAs were organized in genomic clusters representing promoter-controlled miRNA expression and sequence families representing seed-sequence-dependent miRNA-target regulation. Unsupervised clustering of samples by miRNA sequence families best reflected the clustering...
Provenance — who produced it, who reused it
Linked to 8 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Integrated MicroRNA and mRNA Signatures Associated with Survival... 2013 · 179 cites
- Unique somatic and malignant expression patterns implicate PIWI-... 2015 · 167 cites
- microRNA expression profiling identifies a four microRNA signatu... 2014 · 147 cites
- MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and l... 2014 · 103 cites
4 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently