Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis
Background: Histologic grade in breast cancer provides clinically important prognostic information. However, 30%-60% of tumors are classified as histologic grade 2. This grade is associated with an intermediate risk of recurrence and is thus not informative for clinical decision making. We examined whether histologic grade was associated with gene expression profi les of breast cancers and whether such profi les could be used to improve histologic grading. Methods: We analyzed microarray data f...
Provenance — who produced it, who reused it
Linked to 83 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Survival analysis across the entire transcriptome identifies bio... 2021 · 1,740 cites
- Prognostic Significance of Progesterone Receptor–Positive Tumor... 2012 · 589 cites
- A Three-Gene Model to Robustly Identify Breast Cancer Molecular... 2012 · 328 cites
- TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer 2012 · 303 cites
- Elp3 links tRNA modification to IRES-dependent translation of LE... 2016 · 180 cites
- Identification of Prognosis-Relevant Subgroups in Patients with... 2013 · 161 cites
- Defining super-enhancer landscape in triple-negative breast canc... 2021 · 150 cites
- Network of mutually repressive metastasis regulators can promote... 2014 · 148 cites
- Centromere protein-A, an essential centromere protein, is a prog... 2012 · 127 cites
- Shortening of 3′UTRs Correlates with Poor Prognosis in Breast an... 2012 · 123 cites
- Hypoxia-inducible factor 1 mediates TAZ expression and nuclear l... 2014 · 116 cites
- Breast cancer genome and transcriptome integration implicates sp... 2016 · 114 cites
- Meta-analysis of the global gene expression profile of triple-ne... 2014 · 109 cites
- miR-506 Regulates Epithelial Mesenchymal Transition in Breast Ca... 2013 · 100 cites
- Mitohormesis Primes Tumor Invasion and Metastasis 2019 · 94 cites
- Removing batch effects for prediction problems with frozen surro... 2014 · 88 cites
- Reprogramming of Amino Acid Transporters to Support Aspartate an... 2019 · 83 cites
- Bioinformatics analysis of the serine and glycine pathway in can... 2014 · 79 cites
- Integration of mRNA Expression Profile, Copy Number Alterations,... 2014 · 76 cites
61 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently