DNA binding factors shape the mouse methylome at distal regulatory regions [BIS_seq]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylated Regions (LMR) with an average methylation of 30%. These regions are evolutionary conserved, reside outside of CpG islands and distal to promoters. They represent regulatory regions evidenced by the...
Provenance — who produced it, who reused it
Linked to 10 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- High-Resolution Enzymatic Mapping of Genomic 5-Hydroxymethylcyto... 2013 · 175 cites
- Induction of hematopoietic and endothelial cell program orchestr... 2015 · 123 cites
- Structural basis for Klf4 recognition of methylated DNA 2014 · 96 cites
- Enhancer transcribed RNAs arise from hypomethylated, Tet-occupie... 2013 · 74 cites
6 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently