"Off-context" gene expression in lung cancer identifies a group of metastatic-prone tumors
An unexplored consequence of epigenetic alterations associated with cancer is the ectopic expression of tissue-restricted genes. Here, a new strategy was developed to decipher genome-wide expression data in search for these “off-context” gene activations, which consisted first, in identifying a large number of tissue-specific genes normally epigenetically silenced in most somatic cells and second, in using them as cancer biomarkers on an “on/off” basis. Applying this concept to analyze whole-gen...
Provenance — who produced it, who reused it
Linked to 284 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Identification of tumor immune infiltration-associated lncRNAs f... 2020 · 313 cites
- Overall survival prediction of non-small cell lung cancer by int... 2020 · 192 cites
- Robust meta-analysis of gene expression using the elastic net 2015 · 183 cites
- EMT is associated with an epigenetic signature of ECM remodeling... 2019 · 148 cites
- High expression of RRM2 as an independent predictive factor of p... 2020 · 145 cites
- OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorig... 2018 · 143 cites
- Predictability of human differential gene expression 2019 · 137 cites
- p53 mutants cooperate with HIF-1 in transcriptional regulation o... 2018 · 136 cites
- A clonal expression biomarker associates with lung cancer mortal... 2019 · 135 cites
- Profiling cancer testis antigens in non–small-cell lung cancer 2016 · 124 cites
- By integrating single-cell RNA-seq and bulk RNA-seq in sphingoli... 2023 · 122 cites
- High expression levels of pyrimidine metabolic rate–limiting enz... 2020 · 113 cites
- Landscape and dynamics of single tumor and immune cells in early... 2021 · 110 cites
- AIF-regulated oxidative phosphorylation supports lung cancer dev... 2019 · 110 cites
- lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, mig... 2022 · 108 cites
- RNA-binding protein KHSRP promotes tumor growth and metastasis i... 2019 · 103 cites
- Identification of a Ferroptosis-Related LncRNA Signature as a No... 2021 · 93 cites
- Cross-talk between cuproptosis and ferroptosis regulators define... 2023 · 90 cites
- Clinical roles of the aberrantly expressed lncRNAs in lung squam... 2017 · 90 cites
- Overexpression of KIF20A confers malignant phenotype of lung ade... 2018 · 88 cites
- ROCK1 promotes migration and invasion of non‑small‑cell lung can... 2019 · 88 cites
- A large cohort study identifying a novel prognosis prediction mo... 2019 · 86 cites
- Sortilin limits EGFR signaling by promoting its internalization... 2017 · 84 cites
- Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis... 2019 · 84 cites
- FBXO11 promotes ubiquitination of the Snail family of transcript... 2015 · 83 cites
- Identification of prognostic gene signature associated with micr... 2019 · 80 cites
- Signaling pathways activation profiles make better markers of ca... 2014 · 79 cites
- The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeo... 2018 · 78 cites
- USP12 downregulation orchestrates a protumourigenic microenviron... 2021 · 77 cites
- Six-lncRNA Immune Prognostic Signature for Cervical Cancer 2020 · 75 cites
- A seven-long noncoding RNA signature predicts overall survival f... 2018 · 75 cites
- Targeting lactate dehydrogenase a improves radiotherapy efficacy... 2021 · 75 cites
- Comprehensive molecular analyses of a TNF family-based signature... 2020 · 72 cites
- Leveraging mitochondrial-programmed cell death dynamics to enhan... 2024 · 72 cites
- <p>LncRNA MIR210HG promotes proliferation and invasion of... 2019 · 72 cites
44 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.