The evolution of gene expression levels in mammalian organs
Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcripto...
Provenance — who produced it, who reused it
Linked to 26 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Utilizing sequence intrinsic composition to classify protein-cod... 2013 · 2,342 cites
- TEtranscripts: a package for including transposable elements in... 2015 · 825 cites
- Epigenetic conservation at gene regulatory elements revealed by... 2013 · 246 cites
- SQuIRE reveals locus-specific regulation of interspersed repeat... 2019 · 213 cites
- Dexrazoxane may prevent doxorubicin-induced DNA damage via deple... 2014 · 174 cites
- Distinct longevity mechanisms across and within species and thei... 2023 · 149 cites
- Drift and conservation of differential exon usage across tissues... 2013 · 148 cites
- miRIAD—integrating microRNA inter- and intragenic data 2014 · 124 cites
- The evolution of duplicate gene expression in mammalian organs 2017 · 122 cites
- Host gene constraints and genomic context impact the expression... 2016 · 84 cites
16 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently