Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver
Sex-dependent pituitary growth hormone (GH) secretory patterns determine the sex-biased expression of >1,000 genes in mouse and rat liver, affecting lipid and drug metabolism, inflammation and disease. A fundamental biological question is how robust differential expression can be achieved for hundreds of sex-biased genes simply based on the GH input signal pattern: pulsatile GH stimulation in males vs. near-continuous GH exposure in females. STAT5 is an essential transcriptional mediator of the...
Provenance — who produced it, who reused it
Linked to 13 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Hierarchy within the mammary STAT5-driven Wap super-enhancer 2016 · 311 cites
- Genomic modelling of the ESR1 Y537S mutation for evaluating func... 2016 · 178 cites
- Genome-Wide Analysis of Chromatin States Reveals Distinct Mechan... 2013 · 168 cites
- De novo detection of differentially bound regions for ChIP-seq d... 2014 · 132 cites
- Sequential activation of genetic programs in mouse mammary epith... 2012 · 84 cites
- Many chronological aging clocks can be found throughout the epig... 2021 · 71 cites
7 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently