Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives [Illumina Infinium 450K DNA Methylation]
Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and development, drug discovery, and regenerative medicine. However, it is important to identify factors that may impact the utility of hPSCs for these applications. In an unbiased analysis of 205 hPSC and 130 somatic samples, we identified hPSC-specific epigenetic and transcriptional aberrations in genes subject to X chromosome inactivation (XCI) and genomic imprinting, which were not corrected during direc...
Provenance — who produced it, who reused it
Linked to 23 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Ectopic Activation of Germline and Placental Genes Identifies Ag... 2013 · 619 cites
- Identification of differentially methylated cell types in epigen... 2018 · 360 cites
- Pre-clinical study of induced pluripotent stem cell-derived dopa... 2020 · 334 cites
- HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for... 2020 · 181 cites
- An Integrative Multi-scale Analysis of the Dynamic DNA Methylati... 2015 · 167 cites
- A comparison of epigenetic mitotic-like clocks for cancer risk p... 2020 · 153 cites
- Epigenetic clocks reveal a rejuvenation event during embryogenes... 2021 · 121 cites
- DNA Methylation Landscapes of Human Fetal Development 2015 · 110 cites
- MethylResolver—a method for deconvoluting bulk DNA methylation p... 2020 · 91 cites
14 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently