Hypoxic regulation of gene expression is dominated by the HIF system and can be mimicked by DMOG
The response of cells to hypoxia is characterised by co-ordinated regulation of many genes. Studies of the regulation of the expression of many of these genes by oxygen has implicated a role for the heterodimeric transcription factor hypoxia inducible factor (HIF). The mechanism of oxygen sensing which controls this heterodimeric factor is via oxygen dependent prolyl and asparaginyl hydroxylation by specific 2-oxoglutarate dependent dioxygenases (PHD1, PHD2, PHD3 and FIH-1). Whilst HIF appears t...
Provenance — who produced it, who reused it
Linked to 8 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- RNA N6-methyladenosine demethylase FTO promotes breast tumor pro... 2019 · 627 cites
- Characterization of Glycolysis-Associated Molecules in the Tumor... 2020 · 167 cites
- Gene expression profiles of inflammatory breast cancer: correlat... 2013 · 130 cites
5 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently