Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis
The generation of distinctive cell types that form different tissues and organs requires precise, temporal and spatial control of gene expression. This depends on specific cis-regulatory elements distributed in the non-coding DNA surrounding their target genes. Studies performed on mammalian embryonic stem cells and Drosophila embryos suggest that active enhancers form part of a defined chromatin landscape marked by histone H3 lysine 4 mono-methylation (H3K4me1) and histone H3 lysine 27 acetylat...
Provenance — who produced it, who reused it
Linked to 15 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Active DNA demethylation at enhancers during the vertebrate phyl... 2016 · 267 cites
- Systemic Loss and Gain of Chromatin Architecture throughout Zebr... 2018 · 178 cites
- Brd4 and P300 Confer Transcriptional Competency during Zygotic G... 2019 · 176 cites
- Chromatin accessibility established by Pou5f3, Sox19b and Nanog... 2020 · 116 cites
- Convergent evolution of a vertebrate-like methylome in a marine... 2019 · 99 cites
- Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into... 2019 · 96 cites
9 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently