Expression data from human with lupus nephritis (LN)
Nephritis (LN) is a serious manifestation of SLE. Therapeutic studies in mouse LN models do not always predict outcomes of human therapeutic trials, raising concerns about the human relevance of these models. In this study we used an unbiased transcriptional network approach to define similarities and differences between three lupus models and human LN. Affymetrix-based expression profiles were analyzed using Genomatix Bibliosphere software and transcriptional networks were compared using the To...
Provenance — who produced it, who reused it
Linked to 29 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Defining cell-type specificity at the transcriptional level in h... 2013 · 259 cites
- Natural variation of macrophage activation as disease-relevant p... 2017 · 124 cites
- Immune cell infiltration characteristics and related core genes... 2019 · 93 cites
- Organoid single cell profiling identifies a transcriptional sign... 2019 · 89 cites
- CD36 aggravates podocyte injury by activating NLRP3 inflammasome... 2022 · 77 cites
24 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently