Analysis of Pro-Inflammatory Gene Activation and RNA Processing by RNAseq of Nascent Transcripts I
We examined pro-inflammatory gene activation in activated murine macrophages by performing RNA-Seq with fractionated chromatin-associated, nucleoplasmic, and cytoplasmic transcripts. This experimental strategy allowed a global, high-resolution analysis of the transcriptional regulation of diverse classes of co-expressed genes, with a direct comparison to transcript processing and the transit of RNA from the chromatin to the nucleoplasm and the cytoplasm. The results provide quantitative insights...
Provenance — who produced it, who reused it
Linked to 8 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Bidirectional Transcription Arises from Two Distinct Hubs of Tra... 2015 · 240 cites
- Inducible RasGEF1B circular RNA is a positive regulator of ICAM-... 2016 · 157 cites
- Cross-Regulation between TDP-43 and Paraspeckles Promotes Plurip... 2019 · 139 cites
- Divergent transcription is associated with promoters of transcri... 2013 · 106 cites
2 further papers cite this accession but reuse could not be confirmed.
Deep data QC
52/100 · FStandardized, field-standard QC computed by touching the data — every metric states how it was obtained · evidence: measured
The F grade is a transparent weighted average. Each metric below scored from 0–100% against the published bulk-RNA-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0