Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped long-range chromatin interactions associated with RNA polymerase II in human cells and uncovered widespread promoter-centered intragenic, extragenic, and intergenic interactions. These interactions further aggregated into higher-order clusters, wherein proximal and distal genes were engaged thr...
Provenance — who produced it, who reused it
Linked to 16 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Extensive Promoter-Centered Chromatin Interactions Provide a Top... 2012 · 1,315 cites
- Synergistic action of master transcription factors controls epit... 2016 · 126 cites
- Large-Scale Functional Organization of Long-Range Chromatin Inte... 2012 · 122 cites
- GenomicInteractions: An R/Bioconductor package for manipulating... 2015 · 97 cites
- Production of Spliced Long Noncoding RNAs Specifies Regions with... 2018 · 92 cites
- Identification of independent association signals and putative f... 2016 · 75 cites
10 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently