The role of micro-RNA genes in papillary thyroid carcinoma
We show that numerous miRNAs are transcriptionally up-regulated in papillary thyroid carcinoma (PTC) tumors compared with unaffected thyroid tissue. Among the predicted target genes of the three most upregulated miRNAs (miRs 221, 222 and 146b), only less than 15% showed significant downexpression in transcript level between tumor and unaffected tissue. The KIT gene which is known to be downregulated by miRNAs 221 and 222 displayed dramatic loss of transcript and protein in those tumors that ha...
Provenance — who produced it, who reused it
Linked to 42 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator dr... 2017 · 248 cites
- FTO suppresses glycolysis and growth of papillary thyroid cancer... 2022 · 203 cites
- Down-weighting overlapping genes improves gene set analysis 2012 · 162 cites
- LncRNA Gas5 acts as a ceRNA to regulate PTEN expression by spong... 2017 · 110 cites
- Comparative study on gene set and pathway topology-based enrichm... 2015 · 91 cites
- Epithelial tumor suppressor ELF3 is a lineage-specific amplified... 2019 · 71 cites
36 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.