An expression signature for p53 in breast cancer predicts mutation status, transcriptional effects, and patient survival
The biological tumor samples (ie, breast tumor specimens) consisted of freshly frozen breast tumors from a population-based cohort of 315 women representing 65% of all breast cancers resected in Uppsala County, Sweden, from January 1, 1987 to December 31, 1989. Estrogen receptor status was determined by biochemical assay as part of the routine clinical procedure. An experienced pathologist determined the Elston-Ellis grades of the tumors, classifying the tumors into low, medium and high-grade t...
Provenance — who produced it, who reused it
Linked to 170 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Survival analysis across the entire transcriptome identifies bio... 2021 · 1,740 cites
- Metabolic enzyme expression highlights a key role for MTHFD2 and... 2014 · 594 cites
- MYC-driven accumulation of 2-hydroxyglutarate is associated with... 2013 · 470 cites
- Aerobic glycolysis tunes YAP/TAZ transcriptional activity 2015 · 420 cites
- miR-126 and miR-126* repress recruitment of mesenchymal stem cel... 2013 · 351 cites
- A Three-Gene Model to Robustly Identify Breast Cancer Molecular... 2012 · 328 cites
- DeepProg: an ensemble of deep-learning and machine-learning mode... 2021 · 281 cites
- NRF2 activation promotes the recurrence of dormant tumour cells... 2020 · 215 cites
- Opposing Functions of BRD4 Isoforms in Breast Cancer 2020 · 207 cites
- Mutant p53–associated myosin-X upregulation promotes breast canc... 2014 · 183 cites
- Amplification and high-level expression of heat shock protein 90... 2012 · 183 cites
- Claudin-Low Breast Cancer; Clinical & Pathological Character... 2017 · 162 cites
- Identification of Prognosis-Relevant Subgroups in Patients with... 2013 · 161 cites
- Manganese superoxide dismutase promotes anoikis resistance and t... 2013 · 152 cites
- Defining super-enhancer landscape in triple-negative breast canc... 2021 · 150 cites
- CCNA2 Is a Prognostic Biomarker for ER+ Breast Cancer and Tamoxi... 2014 · 149 cites
- Age-Specific Gene Expression Signatures for Breast Tumors and Cr... 2013 · 148 cites
- Network of mutually repressive metastasis regulators can promote... 2014 · 148 cites
- BreastMark: An Integrated Approach to Mining Publicly Available... 2013 · 143 cites
- DEAD-box helicase DP103 defines metastatic potential of human br... 2014 · 131 cites
- A Targeted RNAi Screen of the Breast Cancer Genome Identifies <i... 2013 · 130 cites
- Shortening of 3′UTRs Correlates with Poor Prognosis in Breast an... 2012 · 123 cites
- Anticipatory estrogen activation of the unfolded protein respons... 2014 · 121 cites
- APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen... 2015 · 117 cites
- Hypoxia-inducible factor 1 mediates TAZ expression and nuclear l... 2014 · 116 cites
- Expression profiling of ion channel genes predicts clinical outc... 2013 · 115 cites
- Meta-analysis of the global gene expression profile of triple-ne... 2014 · 109 cites
- FAM83D promotes cell proliferation and motility by downregulatin... 2013 · 108 cites
- The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, an... 2013 · 107 cites
- Biomolecular Events in Cancer Revealed by Attractor Metagenes 2013 · 105 cites
- The RNA binding protein FXR1 is a new driver in the 3q26-29 ampl... 2015 · 101 cites
- Comprehensive Profiling of Amino Acid Response Uncovers Unique M... 2015 · 98 cites
- miR‐10b*, a master inhibitor of the cell cycle, is down‐regulate... 2012 · 95 cites
- The gene expression landscape of breast cancer is shaped by tumo... 2012 · 94 cites
- Mitohormesis Primes Tumor Invasion and Metastasis 2019 · 94 cites
- The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to... 2019 · 92 cites
- Adversarial deconfounding autoencoder for learning robust gene e... 2020 · 87 cites
- The Gene Expression Barcode 3.0: improved data processing and mi... 2013 · 84 cites
- Reprogramming of Amino Acid Transporters to Support Aspartate an... 2019 · 83 cites
- Bioinformatics analysis of the serine and glycine pathway in can... 2014 · 79 cites
33 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.