Genetic recombination is directed away from functional genetic sites in mice.
Genetic recombination occurs during meiosis, the key developmental program of gametogenesis. Recombination in mammals has been recently linked to the activity of a histone H3 methyl-transferase, PRDM9, the product of the only known speciation gene in mammals. PRDM9 is thought to determine the preferred recombination sites - recombination hotspots - through sequence-specific binding of its highly polymorphic multi-Zn-finger domain. Nevertheless, Prdm9 knockout mice are proficient at initiating re...
Provenance — who produced it, who reused it
Linked to 13 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- The Landscape of Mouse Meiotic Double-Strand Break Formation, Pr... 2016 · 324 cites
- Genomic modelling of the ESR1 Y537S mutation for evaluating func... 2016 · 178 cites
- Three-Dimensional Genomic Structure and Cohesin Occupancy Correl... 2019 · 164 cites
- Refined spatial temporal epigenomic profiling reveals intrinsic... 2020 · 79 cites
- Many chronological aging clocks can be found throughout the epig... 2021 · 71 cites
7 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently