ChIP-seq and mRNA-seq experiment to find the direct target genes of ATF4 and CHOP
We report the direct target genes of ATF4 and CHOP in response to endoplasim reticulum stress through next generation sequencing. By obtaining genowide sequence from chromatin immunoprecipitated DNA with anti-CHOP and anit-ATF4, we identified direct binding sites of ATF4 and CHOP in promoter regions of their target genes in mouse embrynic fibroblasts (MEFs) in response to ER stress. In addition, we obtained list of genes which are differentially regulated in Atf4 or Chop-deficient MEFs compared...
Provenance — who produced it, who reused it
Linked to 16 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Multi-omics analysis identifies ATF4 as a key regulator of the m... 2017 · 843 cites
- ATF4 couples MYC-dependent translational activity to bioenergeti... 2019 · 302 cites
- Genomic modelling of the ESR1 Y537S mutation for evaluating func... 2016 · 178 cites
- Inhibiting the integrated stress response pathway prevents aberr... 2018 · 94 cites
- ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eI... 2019 · 92 cites
- Many chronological aging clocks can be found throughout the epig... 2021 · 71 cites
7 further papers cite this accession but reuse could not be confirmed.
Deep data QC
insufficient data to scoreStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
The insufficient grade is a transparent weighted average. Each metric below scored from 0–100% against the published ChIP-seq thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.