Base Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome
The study of 5-hydroxylmethylcytosines (5hmC), the sixth base of the mammalian genome, as an epigenetic mark has been hampered by a lack of method to map it at single-base resolution. Previous affinity purification-based methods could not precisely locate 5hmC nor accurately determine its relative abundance at each modified site. We here present a genome-wide approach for mapping 5hmC at base resolution. Application of this new method to the embryonic stem cells not only confirms widespread d...
Provenance — who produced it, who reused it
Linked to 8 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mamma... 2012 · 1,050 cites
- DNA methylation regulates discrimination of enhancers from promo... 2017 · 142 cites
- Epigenetic Modification, Dehydration, and Molecular Crowding Eff... 2014 · 124 cites
- Subtraction-free and bisulfite-free specific sequencing of 5-met... 2021 · 92 cites
4 further papers cite this accession but reuse could not be confirmed.
Deep data QC
insufficient data to scoreStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
The insufficient grade is a transparent weighted average. Each metric below scored from 0–100% against the published methylation thresholds, weighted by its importance; nothing is hidden or subjective.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0