Transcriptional Amplification in Tumor Cells with Elevated c-Myc
Excessive expression of c-Myc occurs frequently in human cancers, where high levels are associated with tumor aggression and poor clinical outcome, but the effect of high levels of c-Myc on global gene regulation is poorly understood. We report here that in tumor cells expressing high levels of c-Myc, the transcription factor binds to E-box sequences in the core promoters of most actively transcribed genes and, unexpectedly, the enhancers of these active genes. The predominant effect of increa...
Provenance — who produced it, who reused it
Linked to 12 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- The MYC Oncogene Cooperates with Sterol-Regulated Element-Bindin... 2019 · 200 cites
- Synergistic action of master transcription factors controls epit... 2016 · 126 cites
- MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by... 2017 · 114 cites
- Myc-induced SUMOylation is a therapeutic vulnerability for B-cel... 2014 · 95 cites
- Sequence specificity incompletely defines the genome-wide occupa... 2014 · 83 cites
6 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently