Molecular Genetic Classification of clear-cell Renal Cell Carcinoma (ccRCC) based on the Gene Expression Profiling of Tumors and Tumorgrafts deficient for BAP1 or PBRM1
Renal cell carcinoma (RCC) exhibits some unusual features and genes commonly mutated in cancer are rarely mutated in clear-cell RCC (ccRCC), the most common type. The most prevalent genetic alteration in ccRCC is the inactivation of the tumor suppressor gene VHL. Using whole-genome and exome sequencing we discovered BAP1 as a novel tumor suppressor in ccRCC that shows little overlap with mutations in PBRM1, another recent tumor suppressor. Whereas VHL was mutated in 81% of the patients (142/176)...
Provenance — who produced it, who reused it
Linked to 54 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Tumor‐suppressive <i>micro<scp>RNA</scp>‐143/145</i> cluster tar... 2013 · 137 cites
- Simultaneous isolation of high-quality DNA, RNA, miRNA and prote... 2013 · 129 cites
- Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2... 2016 · 119 cites
- Multi-omics identification of an immunogenic cell death-related... 2023 · 103 cites
- Tumor‐suppressive <i>micro<scp>RNA</scp>‐1291</i> directly regul... 2013 · 95 cites
- Extreme Downregulation of Chromosome Y and Cancer Risk in Men 2019 · 86 cites
- microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis... 2017 · 73 cites
47 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently