Subgroup specific somatic copy number aberrations in the medulloblastoma genome
Medulloblastoma, the most common malignant pediatric brain tumour is currently treated with non-specific cytotoxic therapies including surgery, whole brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, prior attempts to identify targets for therapy have been underpowered due to small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1087 unique medulloblastomas. SCNA...
Provenance — who produced it, who reused it
Linked to 10 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Functional Enhancers Shape Extrachromosomal Oncogene Amplificati... 2019 · 365 cites
- BET Bromodomain Inhibition of <i>MYC</i> -Amplified Medulloblast... 2013 · 350 cites
- Enhancer hijacking determines extrachromosomal circular MYCN amp... 2020 · 228 cites
- Recurrent noncoding U1 snRNA mutations drive cryptic splicing in... 2019 · 172 cites
- Failure of human rhombic lip differentiation underlies medullobl... 2022 · 160 cites
- The transcriptional landscape of Shh medulloblastoma 2021 · 94 cites
- NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Sp... 2018 · 74 cites
2 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently