Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis and tissue microarray validation
Background: Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict prognosis and therapy response. So far, the value of these multi-gene signatures in clinical practice is unclear and the biological importance of individual genes is difficult to assess as the published signatures virtually do not overlap. Methods: Here we describe a novel single institute cohort, including 196 non-small lung cancer (...
Provenance — who produced it, who reused it
Linked to 160 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Overall survival prediction of non-small cell lung cancer by int... 2020 · 192 cites
- A potential signature of eight long non-coding RNAs predicts sur... 2015 · 174 cites
- EMT is associated with an epigenetic signature of ECM remodeling... 2019 · 148 cites
- Profiling cancer testis antigens in non–small-cell lung cancer 2016 · 124 cites
- By integrating single-cell RNA-seq and bulk RNA-seq in sphingoli... 2023 · 122 cites
- Selective poly adenylation predicts the efficacy of immunotherap... 2022 · 120 cites
- The Long Noncoding RNA MALAT-1 is A Novel Biomarker in Various C... 2016 · 112 cites
- Landscape and dynamics of single tumor and immune cells in early... 2021 · 110 cites
- Characterization of a ferroptosis and iron-metabolism related ln... 2021 · 96 cites
- A Robust 8-Gene Prognostic Signature for Early-Stage Non-small C... 2019 · 95 cites
- A large cohort study identifying a novel prognosis prediction mo... 2019 · 86 cites
- Sortilin limits EGFR signaling by promoting its internalization... 2017 · 84 cites
- FBXO11 promotes ubiquitination of the Snail family of transcript... 2015 · 83 cites
- Relapse-related long non-coding RNA signature to improve prognos... 2016 · 79 cites
- The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeo... 2018 · 78 cites
- A seven-long noncoding RNA signature predicts overall survival f... 2018 · 75 cites
- Targeting lactate dehydrogenase a improves radiotherapy efficacy... 2021 · 75 cites
- Eight potential biomarkers for distinguishing between lung adeno... 2017 · 74 cites
62 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently