Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
Genome wide DNA methylation profiling of individuals across a large age range. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450k CpGs from human whole blood.
Provenance — who produced it, who reused it
Linked to 74 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Aging of blood can be tracked by DNA methylation changes at just... 2014 · 955 cites
- Identification of tissue-specific cell death using methylation p... 2016 · 621 cites
- Improved precision of epigenetic clock estimates across tissues... 2019 · 509 cites
- Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Ye... 2016 · 320 cites
- Improving cell mixture deconvolution by identifying optimal DNA... 2016 · 230 cites
- Estimation of a significance threshold for epigenome‐wide associ... 2017 · 206 cites
- Cell-type-specific resolution epigenetics without the need for c... 2019 · 182 cites
- Concordant and discordant DNA methylation signatures of aging in... 2015 · 158 cites
- DeepMAge: A Methylation Aging Clock Developed with Deep Learning 2021 · 158 cites
- A comparison of epigenetic mitotic-like clocks for cancer risk p... 2020 · 153 cites
- Epigenetic Aging Signatures Are Coherently Modified in Cancer 2015 · 137 cites
- Quantitative Translation of Dog-to-Human Aging by Conserved Remo... 2020 · 135 cites
- MethylNet: an automated and modular deep learning approach for D... 2020 · 133 cites
- DNA Methylation Profiling of Uniparental Disomy Subjects Provide... 2016 · 122 cites
- Refining epigenetic prediction of chronological and biological a... 2023 · 115 cites
- Aging clocks based on accumulating stochastic variation 2024 · 112 cites
- The lipid elongation enzyme ELOVL2 is a molecular regulator of a... 2020 · 108 cites
- TOAST: improving reference-free cell composition estimation by c... 2019 · 105 cites
- DNA methylation-driven EMT is a common mechanism of resistance t... 2020 · 104 cites
- Removing unwanted variation in a differential methylation analys... 2015 · 103 cites
- Ageing-associated DNA methylation dynamics are a molecular reado... 2018 · 103 cites
- Methylomic Aging as a Window onto the Influence of Lifestyle: To... 2015 · 99 cites
- DNA Methylation Signature for EZH2 Functionally Classifies Seque... 2020 · 82 cites
- Novel region discovery method for Infinium 450K <scp>DNA</scp> m... 2013 · 79 cites
- Human Age Prediction Based on DNA Methylation Using a Gradient B... 2018 · 79 cites
- DNA methylation signatures reflect aging in patients with nonalc... 2018 · 79 cites
- Human epigenetic ageing is logarithmic with time across the enti... 2019 · 77 cites
46 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently
Scientific quality
Based on hands-on reproduction of the papers that use this dataset. A reproducible paper that stands on this data is positive evidence; a flagged one is a prompt to look closer — never a verdict on the dataset itself without the evidence.