A cancer associated fibroblasts (CAFs) specific gene signature in high grade serous ovarian cancer
Ovarian cancer is the most lethal malignancy in the United States. In the year 2012, there will be an estimated 22,280 new cases and 15,500 deaths from ovarian cancer in the country (Siegel et al., 2012). While studies on ovarian cancer pathogenesis were mainly focused on the epithelial component of the tumor, understanding in the role of cancer associated fibroblasts (CAFs) in ovarian cancer progression is limited. We hypothesized that comparing the gene expression profiles of different compone...
Provenance — who produced it, who reused it
Linked to 44 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor... 2016 · 435 cites
- A mathematical-descriptor of tumor-mesoscopic-structure from com... 2019 · 215 cites
- Co-evolution of matrisome and adaptive adhesion dynamics drives... 2021 · 173 cites
- Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressi... 2019 · 170 cites
- ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferat... 2020 · 148 cites
- Downregulation of MYPT1 increases tumor resistance in ovarian ca... 2020 · 121 cites
- Integrated bioinformatics analysis for the screening of hub gene... 2020 · 110 cites
37 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently