Expression profiling in early onset colorectal cancer
Background: Causative genes for autosomal dominantly inherited familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC) have been well characterized. There is, however, another 10-15 % early onset colorectal cancer (CRC) whose genetic components are currently unknown. In this study, we used DNA chip technology to systematically search for genes differentially expressed in early onset CRC.
Provenance — who produced it, who reused it
Linked to 53 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- The NLRP1 Inflammasome Attenuates Colitis and Colitis-Associated... 2015 · 163 cites
- Down-weighting overlapping genes improves gene set analysis 2012 · 162 cites
- Long non-coding RNA RP11-468E2.5 curtails colorectal cancer cell... 2019 · 144 cites
- Notch1 counteracts WNT/β-catenin signaling through chromatin mod... 2012 · 133 cites
- Comparative study on gene set and pathway topology-based enrichm... 2015 · 91 cites
- GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice... 2019 · 89 cites
- A distinct p53 target gene set predicts for response to the sele... 2015 · 87 cites
- An integrative analysis reveals functional targets of GATA6 tran... 2013 · 81 cites
- Intestinal Sulfation Is Essential to Protect Against Colitis and... 2021 · 81 cites
- Ranking metrics in gene set enrichment analysis: do they matter? 2017 · 80 cites
43 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently