Gene expression profiling of colorectal normal mucosa, adenoma and adenocarcinoma tissues
Approximately two decades ago, Vogelstein and Fearon proposed the adenoma-carcinoma sequence of sporadic CRC development and illustrated the accumulation of genetic alterations during the stepwise progression, thereby providing a guideline for clinical practice. Although the detection and excision of precancerous lesions could prevent colorectal cancer and reduce mortality, 6% of adenomas will ultimately develop into colorectal cancer. Thus, this genetic model for colorectal tumorigenesis may no...
Provenance — who produced it, who reused it
Linked to 25 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- METTL14-mediated N6-methyladenosine modification of SOX4 mRNA in... 2020 · 447 cites
- N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis an... 2021 · 122 cites
- KIF20A promotes cellular malignant behavior and enhances resista... 2019 · 80 cites
22 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently