A Cell Epigenotype Specific Model for the Correction of Cellular Heterogeneity in the Brain
Cellular heterogeneity may bias cell type specific epigenetic patterns leading to a dramatic increase in false positive or negative findings in psychiatric epigenetic studies. To address this issue, we performed fluorescence activated cell sorting (FACS) of neuronal nuclei in post mortem frontal cortex 58 samples followed by Illumina HM450 microarray based DNA methylation profiling. We characterized the extent of neuron and glia specific DNA methylation variation independent of disease status an...
Provenance — who produced it, who reused it
Linked to 26 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- DNA methylation markers for diagnosis and prognosis of common ca... 2017 · 496 cites
- Comprehensive Analysis of Genetic Ancestry and Its Molecular Cor... 2020 · 326 cites
- DNA methylation analysis on purified neurons and glia dissects a... 2018 · 256 cites
- Inferring regulatory element landscapes and transcription factor... 2015 · 219 cites
- Estimation of a significance threshold for epigenome‐wide associ... 2017 · 206 cites
- Measuring cell-type specific differential methylation in human b... 2013 · 123 cites
- Deconvolution of cellular subsets in human tissue based on targe... 2020 · 84 cites
- A survey of inter-individual variation in DNA methylation identi... 2018 · 79 cites
- Sexually divergent <scp>DNA</scp> methylation patterns with hipp... 2017 · 76 cites
16 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently