Transcriptomic profiling in childhood H1N1/09 influenza reveals reduced expression of protein synthesis genes
In order to understand the immunopathogenesis of severe influenza H1N1/09, we compared the whole blood RNA transcriptome of children hospitalised with H1N1/09 infection with that of children hospitalised with RSV or bacterial infection Blood was collected into PAX gene tubes (PreAnalytiX). Total RNA integrity was assessed using an Agilent 2100 Bioanalyzer (Agilent, Palo Alto, CA). Labeled cRNA was hybridized to Illumina Human HT-12 v3 Beadchips.
Provenance — who produced it, who reused it
Linked to 12 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Host gene expression classifiers diagnose acute respiratory illn... 2016 · 268 cites
- A modular transcriptional signature identifies phenotypic hetero... 2018 · 239 cites
- Inhibiting the Evolution of Antibiotic Resistance 2018 · 204 cites
- Interpretation of biological experiments changes with evolution... 2018 · 193 cites
- Global gene expression profiling identifies new therapeutic targ... 2014 · 169 cites
7 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently