Disrupted functional neworks in autism underlie early brain maldevelopment and provide accurate classification
The disrupted genetic mechanisms underlying neural abnormalities in Autism Spectrum Disorder remain mostly unknown and speculative. No biological marker nor genetic signature is currently available to assist with early diagnosis. We identified a blood-based gene expression signature relevant to the brain pathophysiology in autism. Also we identified genes that are differentially expressed in ASD subjects vs controls and gene modules that efficiently classify ASD and TD subjects.
Provenance — who produced it, who reused it
Linked to 10 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Combined expressional analysis, bioinformatics and targeted prot... 2015 · 108 cites
- Investigation of epigenetic regulatory networks associated with... 2018 · 72 cites
8 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently