Tissue-specific methylomes reveal epigenetic memory in adult mouse tissue
Cytosine methylation of DNA is an evolutionarily conserved mechanism from plants to animals with crucial roles in gene regulation. However, the variation between methylomes of normal tissues is largely unexplored. To better understand the epigenetic variation of a normal individual, we profiled DNA methylation using whole genome bisulfite sequencing in 17 tissues isolated from an individual mouse. We observed a unique distribution of CpG methylation for each tissue, which cluster based on cell l...
Provenance — who produced it, who reused it
Linked to 15 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Epigenetic memory at embryonic enhancers identified in DNA methy... 2013 · 507 cites
- Genome-wide analysis in the mouse embryo reveals the importance... 2020 · 163 cites
- Epigenetic regulator function through mouse gastrulation 2020 · 157 cites
- DNA methylation regulates discrimination of enhancers from promo... 2017 · 142 cites
- Early Developmental and Evolutionary Origins of Gene Body DNA Me... 2015 · 122 cites
- Postnatal DNA demethylation and its role in tissue maturation 2018 · 84 cites
- Polycomb repressive complex 1 shapes the nucleosome landscape bu... 2018 · 75 cites
8 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently