Genetic Programs in Human and Mouse Early Embryos Revealed by Single-Cell RNA-Sequencing
Mammalian preimplantation development is a complex process involving dramatic changes in the transcriptional architecture. Through single-cell RNA-sequencing (RNA-seq), we report here a comprehensive analysis of transcriptome dynamics from oocyte to morula in both human and mouse embryos. Based on single nucleotide variants (SNVs) in blastomere mRNAs and paternal-specific SNPs, we identify novel stage-specific monoallelic expression patterns for a significant portion of polymorphic gene transcri...
Provenance — who produced it, who reused it
Linked to 31 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Broad histone H3K4me3 domains in mouse oocytes modulate maternal... 2016 · 662 cites
- scMerge leverages factor analysis, stable expression, and pseudo... 2019 · 207 cites
- 8C-like cells capture the human zygotic genome activation progra... 2022 · 156 cites
- Human embryonic genome activation initiates at the one-cell stag... 2021 · 130 cites
- Imputing single-cell RNA-seq data by combining graph convolution... 2021 · 110 cites
- A Single-Cell Transcriptomics CRISPR-Activation Screen Identifie... 2020 · 96 cites
- The landscape of human mutually exclusive splicing 2017 · 75 cites
23 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently