Activation and repression by oncogenic Myc shapes tumour-specific gene expression profiles
In mammalian cells, the Myc oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, Myc promotes an increase in expression of virtually all genes. In contrast, Myc-driven tumour cells differ from normal cells in expression of specific sets of up- and downregulated genes that have significant prognostic value. To understand this discrepancy, we studied the consequences of inducible expression and depletion of Myc in human cells and murine tumour models. C...
Provenance — who produced it, who reused it
Linked to 9 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Activation and repression by oncogenic MYC shape tumour-specific... 2014 · 527 cites
- MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Tra... 2019 · 143 cites
- BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple... 2014 · 84 cites
6 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently