Multi-tissue gene expression profiles of human brain (PFC)
The genetics of complex disease produce alterations in molecular interactions of cellular pathways which collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer´s disease (LOAD), we constructed gene regulatory networks in hundreds of autopsied brain tissues from LOAD patients and non-demented subjects. We demonstrate that LOAD reconfigures specific portions of the molecular interaction struct...
Provenance — who produced it, who reused it
Linked to 25 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Integrated Systems Approach Identifies Genetic Nodes and Network... 2013 · 1,762 cites
- DNA polymerase β deficiency leads to neurodegeneration and exace... 2014 · 139 cites
- Multi-transcriptomic analysis points to early organelle dysfunct... 2022 · 90 cites
- Integrative genomics approach identifies conserved transcriptomi... 2020 · 83 cites
- Integrated multi-omics analysis of Alzheimer’s disease shows mol... 2023 · 77 cites
20 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently