Identification and Characterization of the Mammalian Nuclear RNA N6-Adenosine Methyltransferase Core Complex
N6-methyladenosine (m6A) is the most prevalent internal modification found in mammalian messenger and non-coding RNAs. The discoveries of functionally significant demethylases that reverse this methylation as well as the recently revealed m6A distributions in mammalian transcriptomes strongly indicate regulatory functions of this modification. Here we report the identification and characterization of the mammalian nuclear RNA N6-adenosine methyltransferase core (RNMTC) complex. Besides METTL3, a...
Provenance — who produced it, who reused it
Linked to 16 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- WTAP facilitates progression of hepatocellular carcinoma via m6A... 2019 · 669 cites
- METTL16 exerts an m6A-independent function to facilitate transla... 2022 · 353 cites
- Transcriptome-wide profiling and quantification of N6-methyladen... 2023 · 195 cites
- WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 ex... 2020 · 141 cites
- A novel algorithm for calling mRNA m 6 A peaks by modeling biolo... 2016 · 129 cites
- m<sup>6</sup>A RNA modification modulates PI3K/Akt/mTOR signal p... 2020 · 100 cites
- YTHDF1 Aggravates the Progression of Cervical Cancer Through m6A... 2021 · 75 cites
9 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently