Global DNA methylation alterations reveal multiple pathways in the initiation and progression of colorectal cancer
Genetic and epigenetic alterations are a fundamental aspect of colorectal cancer formation. There is considerable heterogeneity between colorectal cancers regarding the mutations and methylated genes they carry, and this heterogeneity may arise early in the polyp-cancer sequence. However, our understanding of the epigenetic alterations and gene mutations in colon adenomas and their relation to colorectal cancer is incomplete. Thus, we have assessed the methylome in normal colon mucosa, tubula...
Provenance — who produced it, who reused it
Linked to 28 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Differences in DNA Methylation Signatures Reveal Multiple Pathwa... 2014 · 224 cites
- Bacteria pathogens drive host colonic epithelial cell promoter h... 2020 · 146 cites
- VARIDT 1.0: variability of drug transporter database 2019 · 132 cites
- Integrative analysis identifies potential DNA methylation biomar... 2019 · 128 cites
- Aberrant DNA methylation of WNT pathway genes in the development... 2016 · 81 cites
- Aging related methylation influences the gene expression of key... 2016 · 78 cites
- A suite of DNA methylation markers that can detect most common h... 2017 · 72 cites
21 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently