m6A-dependent regulation of messenger RNA stability
N6-methyladenosine (m6A) is the most prevalent internal modification present in the mRNA of all higher eukaryotes. Here we present that m6A is selectively recognized by human YTH domain family (YTHDF2) protein to regulate mRNA degradation. By using crosslinking and immunoprecipitation, we have identified over 4000 substrate RNA of YTHDF2 with conserved core motif of G(m6A)C. We further estabilshed the role of YTHDF2 in RNA metabolism by a combination of ribosome profiling, RNA sequencing, m6A le...
Provenance — who produced it, who reused it
Linked to 13 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- A Unified Model for the Function of YTHDF Proteins in Regulating... 2020 · 855 cites
- R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia b... 2021 · 345 cites
- Transcriptome-wide profiling and quantification of N6-methyladen... 2023 · 195 cites
- METTL3 promotes tumour development by decreasing APC expression... 2021 · 193 cites
- METTL3 restrains papillary thyroid cancer progression via m6A/c-... 2021 · 191 cites
- Multiple links between 5-methylcytosine content of mRNA and tran... 2020 · 182 cites
- METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis thr... 2021 · 87 cites
- riboCIRC: a comprehensive database of translatable circRNAs 2021 · 82 cites
- Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with... 2022 · 71 cites
3 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently