Differential Protein Occupancy Profiling of the mRNA Transcriptome
Protein-RNA interactions are fundamental to core biological processes, such as mRNA splicing, localization, degradation and translation. We have developed a photoreactive nucleotide-enhanced UV crosslinking and oligo(dT) purification approach to identify the mRNA-bound proteome using quantitative proteomics and to display the protein occupancy on mRNA transcripts by next-generation sequencing (Baltz and Munschauer et al. 2012). Our current work focuses on streamlining and extending protein occup...
Provenance — who produced it, who reused it
Linked to 6 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Intrinsic Dynamics of a Human Gene Reveal the Basis of Expressio... 2018 · 295 cites
- Characterization of fusion genes and the significantly expressed... 2015 · 128 cites
- Predictive models of subcellular localization of long RNAs 2019 · 118 cites
- Differential protein occupancy profiling of the mRNA transcripto... 2014 · 104 cites
2 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently