Validation of a histology-independent prognostic gene signature for early stage, non-small cell lung cancer including stage IA patients
Background: Patients with early stage non-small cell lung carcinoma (NSCLC) may benefit from treatments based on more accurate prognosis. A 15-gene prognostic classifier for NSCLC was identified from mRNA expression profiling of tumor samples from the NCIC CTG JBR.10 trial. Here, we assessed its value in an independent set of cases. Methods: Expression profiling was performed on RNA from frozen, resected tumor tissues corresponding to 181 Stage I and II NSCLC cases collected at University Health...
Provenance — who produced it, who reused it
Linked to 214 papers in the literature. Roles are inferred factual signals (who deposited the data vs who reused it), with counts — never a judgement about any author.
- Overall survival prediction of non-small cell lung cancer by int... 2020 · 192 cites
- A potential signature of eight long non-coding RNAs predicts sur... 2015 · 174 cites
- A clonal expression biomarker associates with lung cancer mortal... 2019 · 135 cites
- Profiling cancer testis antigens in non–small-cell lung cancer 2016 · 124 cites
- The Long Noncoding RNA MALAT-1 is A Novel Biomarker in Various C... 2016 · 112 cites
- Landscape and dynamics of single tumor and immune cells in early... 2021 · 110 cites
- A Robust 8-Gene Prognostic Signature for Early-Stage Non-small C... 2019 · 95 cites
- A large cohort study identifying a novel prognosis prediction mo... 2019 · 86 cites
- Extracellular matrix profiles determine risk and prognosis of th... 2022 · 85 cites
- Sortilin limits EGFR signaling by promoting its internalization... 2017 · 84 cites
- FBXO11 promotes ubiquitination of the Snail family of transcript... 2015 · 83 cites
- Identification of prognostic gene signature associated with micr... 2019 · 80 cites
- Relapse-related long non-coding RNA signature to improve prognos... 2016 · 79 cites
- The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeo... 2018 · 78 cites
- A seven-long noncoding RNA signature predicts overall survival f... 2018 · 75 cites
- Targeting lactate dehydrogenase a improves radiotherapy efficacy... 2021 · 75 cites
- Eight potential biomarkers for distinguishing between lung adeno... 2017 · 74 cites
63 further papers cite this accession but reuse could not be confirmed.
Deep data QC
metadata only · no data-level QC for this typeStandardized, field-standard QC computed by touching the data — every metric states how it was obtained
No quantitative QC rubric exists for this data type yet, so it is deliberately left unscored — this is an honest "not applicable", not a poor rating.
measured = computed from the data · extrapolated/reported = derived or from the repository · dq-1.0 · provisional — verify independently